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Vitamin D

Vitamin D is a fat soluble vitamin regulating calcium and phosphate metabolism by increasing their gut absorption and stimulating retention by the kidneys.

Vitamin D is significant clinically because of the interrelationship with calcium homeostasis and bone metabolism. It promotes the mineralization of bones and teeth, as well as having a role in neuromuscular function. Vitamin D is converted in the liver to 25-hydroxyvitamin D (25[OH]D), the major circulating form of vitamin D, and then to 1,25-dihydroxyvitamin D in the kidney, the active metabolite. Deficiency results in inadequate mineralisation of bone matrix resulting in rickets in children and osteomalacia in adults.

Clinical Details

A circulating level of 25-hydroxyvitamin D > 50nmol/l indicates a normal level.  30 – 50 nmol/L suggests vitamin D insufficiency.  < 30nmol/L suggests vitamin D deficiency.

Prolonged or chronic deficiency of 25(OH)D levels lead to low calcium and phosphate absorption, resulting in hypocalcaemia. As a result, PTH concentrations rise leading to secondary hyperparathyroidism. This prompts the accelerated bone loss process, resulting in osteomalacia in adults and rickets in children.

The main causes of vitamin D deficiency are inadequate dietary intake and insufficient sunlight exposure. Other causes are due to:
  • Malabsorption – bariatric surgery or post gastrectomy, chronic pancreatic disease, cystic fibrosis, Crohns disease, coeliac disease, biliary disease – PBC, strictures.
  • Chronic kidney disease causing defective synthesis of 1,25-dihydroxyvitamin synthesis.
  • Liver dysfunction impairing the production of 25-hydroxyvitamin D.
  • Drug related : anticonvulsants, HAART, rifampicin.
  • End organ resistance to vitamin D metabolites (hereditary vitamin D resistant rickets).
  • Patients with a history of extensive burns due to inefficient vitamin D synthesis in the skin.
At risk groups of vitamin D deficiency:
  • People confined indoors – often older patients residing in nursing homes, those needing prolonged hospital stays, housebound, institutionalised groups.
  • Over 65 year olds.
  • Increased skin pigmentation.
  • Malabsorption – coeliac disease, post gastrectomy, cystic fibrosis, IBD.
  • Pregnant and breast feeding women.
  • Inadequate daily sun exposure due dermatological conditions adversely affected by sunlight requiring additional SPF applications or full barrier clothing to protect the skin, or for individuals who cover their skin for cultural reasons.

 

Case Study
At Enfer Medical, we have integrated a cutting-edge and fully automated WASPLab® (Walk Away Specimen Processor) that has significantly enhanced our testing capabilities to ensure the highest of quality when processing patient samples.
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WASPLab® at Enfer Medical
Our entire microbiology workflow has been optimized using automation and highly sophisticated robots to ensure uninterrupted incubation for rapid bacterial growth and improved turnaround times for patients.
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Our Services

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Health & Wellness
General health and wellness testing can include a variety of tests, depending on the needs of the individual or recommendations of
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Sample Type &
Volume Required

5mL venous serum

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Transporting
Samples

In addition to the packaging of samples, the transport/delivery of clinical samples to the laboratory is required to be in adherence to all national regulations for the safe transport of biological materials. Enfer Medical provides a fully compliant logistics service, aligned with clients’ testing requirements.

Prompt transport of specimens:
To ensure prompt testing of samples and release of results within the published test turnaround times, samples should arrive to the laboratory by 18:00. Test turnaround time is measured from receipt of the sample at the laboratory until the time the authorised results are reported to users.

Acceptance/Rejection
of Samples

In rare cases specimens may not be suitable for testing on arrival to the laboratory. In that case the sample will be rejected at the receipt stage and the service user will be notified immediately and an explanation as to why the sample could not be processed will be provided. Reasons why samples cannot be processed include but are not limited to:

  • Samples received beyond the stability limits and/or not at the correct temperature indicated for each test.
  • Incorrect sample type received.
  • Leaking samples, sample not received or sample insufficient for analysis as stated below within sample requirements.
  • Non-compliant samples or request forms i.e. those missing sample date information, missing sample test request and/or missing sample site/type information.
  • Samples received without the necessary patient identifiers.
Clients will be provided with guidance on Sample Receipt Anomalies.

Our Services

Service
Health & Wellness
General health and wellness testing can include a variety of tests, depending on the needs of the individual or recommendations of
Find Out More
Service
Sexual Health
Regular STI screening facilitates early treatment and reduces the long-term consequences of infection.
Find Out More
Service
Respiratory Health
Rapid early pathogen identification has important treatment and infection control implications. See our range of tests here.
Find Out More
Service
Reproductive & Female Health
Hormonal analysis is hugely beneficial to identifying problems that can arise during the reproductive years.
Find Out More
Service
All Services
View the full suite of services at Enfer Medical here.......
Find Out More
Result Values:

Quantitative results for Vitamin D are reported in numeric value in nmol/L. Please contact us for more information on the reference ranges used at Enfer Medical.

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