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SARS-CoV-2 anti-Spike

This assay measures IgG antibodies against the spike RBD of SARS-CoV-2.

COVID-19 vaccination elicits antibodies against the SARS-CoV-2 proteins including nucleocapsid and spike. Serological tests which detect antibodies to this spike protein can be used as an aid in the diagnosis of SARS-CoV-2 infection in conjunction with clinical presentation and other laboratory tests.

The assay is also to be used as an aid in evaluating the immune status of infected individuals and to monitor antibody response in individuals that have received the COVID-19 vaccine.

 

Clinical Details

The host immune system reacts to COVID-19 disease by producing SARS-CoV-2 specific antibodies. These antibodies appear in serum or plasma of infected individuals after the detection of viral ribonucleic acid (RNA) in swabs and are detectable 3-14 days after the onset of symptoms. SARS-CoV-2 specific IgG antibodies are detectable in COVID-19 patients during the symptomatic phase of the disease and after viral RNA is no longer detectable. The sensitivity of combining RNA with antibody results for the diagnosis of COVID-19 infection has been reported to be > 99%. The persistence of IgG antibodies allows identification of individuals who have been vaccinated against SARS-CoV-2, or those who were infected in the past, recovered from the illness, and developed a degree of immunity to the disease.

The SARS-CoV-2 anti-spike IgG assay quantifies the concentration of SARS-CoV-2 IgG in the blood of individuals who have been infected with, or are vaccinated against COVID-19, giving results in the form of Arbitrary Units / Millilitre (AU/ml). Higher titre antibody responses have been observed in patients with more severe illness as compared with mildly symptomatic or asymptomatic individuals. Research is ongoing to establish the extent to which IgG antibodies to SARS-CoV-2 confer immunity to infection.

SARS-CoV-2 antibody tests are not used to diagnose current or active infection.

Case Study
At Enfer Medical, we have integrated a cutting-edge and fully automated WASPLab® (Walk Away Specimen Processor) that has significantly enhanced our testing capabilities to ensure the highest of quality when processing patient samples.
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WASPLab® at Enfer Medical
Our entire microbiology workflow has been optimized using automation and highly sophisticated robots to ensure uninterrupted incubation for rapid bacterial growth and improved turnaround times for patients.
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Our Services

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Health & Wellness
General health and wellness testing can include a variety of tests, depending on the needs of the individual or recommendations of
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Sexual Health
Regular STI screening facilitates early treatment and reduces the long-term consequences of infection.
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Respiratory Health
Rapid early pathogen identification has important treatment and infection control implications. See our range of tests here.
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Hormonal analysis is hugely beneficial to identifying problems that can arise during the reproductive years.
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Sample Type &
Volume Required

5mL venous serum or plasma.

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Transporting
Samples

In addition to the packaging of samples, the transport/delivery of clinical samples to the laboratory is required to be in adherence to all national regulations for the safe transport of biological materials. Enfer Medical provides a fully compliant logistics service, aligned with clients’ testing requirements.

Prompt transport of specimens:
To ensure prompt testing of samples and release of results within the published test turnaround times, samples should arrive to the laboratory by 18:00. Test turnaround time is measured from receipt of the sample at the laboratory until the time the authorised results are reported to users.

Acceptance/Rejection
of Samples

In rare cases specimens may not be suitable for testing on arrival to the laboratory. In that case the sample will be rejected at the receipt stage and the service user will be notified immediately and an explanation as to why the sample could not be processed will be provided. Reasons why samples cannot be processed include but are not limited to:

  • Samples received beyond the stability limits and/or not at the correct temperature indicated for each test.
  • Incorrect sample type received.
  • Leaking samples, sample not received or sample insufficient for analysis as stated below within sample requirements.
  • Non-compliant samples or request forms i.e. those missing sample date information, missing sample test request and/or missing sample site/type information.
  • Samples received without the necessary patient identifiers.
Clients will be provided with guidance on Sample Receipt Anomalies.

Our Services

Service
Health & Wellness
General health and wellness testing can include a variety of tests, depending on the needs of the individual or recommendations of
Find Out More
Service
Sexual Health
Regular STI screening facilitates early treatment and reduces the long-term consequences of infection.
Find Out More
Service
Respiratory Health
Rapid early pathogen identification has important treatment and infection control implications. See our range of tests here.
Find Out More
Service
Reproductive & Female Health
Hormonal analysis is hugely beneficial to identifying problems that can arise during the reproductive years.
Find Out More
Service
All Services
View the full suite of services at Enfer Medical here.......
Find Out More
Result Values:
The SARS-CoV-2 anti-spike IgG assay quantifies the concentration of SARS-CoV-2 IgG in the blood of individuals who have been infected with, or are vaccinated against COVID-19, giving results in the form of Arbitrary Units / Millilitre (AU/ml).
Quantitative results
  • DETECTED (Numerical result range: 50-1,000,000 AU/ml)
  • NOT DETECTED
  • INVALID
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Our Services

Service
Health & Wellness
General health and wellness testing can include a variety of tests, depending on the needs of the individual or recommendations of
Find Out More
Service
Sexual Health
Regular STI screening facilitates early treatment and reduces the long-term consequences of infection.
Find Out More
Service
Respiratory Health
Rapid early pathogen identification has important treatment and infection control implications. See our range of tests here.
Find Out More
Service
Reproductive & Female Health
Hormonal analysis is hugely beneficial to identifying problems that can arise during the reproductive years.
Find Out More
Service
All Services
View the full suite of services at Enfer Medical here.......
Find Out More