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Aspergillus Glactomannan Antigen


Aspergillus Glactomannan Antigen

Aspergillus species are fungi that are ubiquitous in the environment and may cause a wide range of clinical manifestations in a susceptible host. Invasive aspergillosis in an immunocompromised host and is associated with significant morbidity and mortality

Early diagnosis is vital to ensure appropriate antifungal treatment is commenced without delay. Galactomannan, a cell wall component of Aspergillus, and 1-3 β-D-glucan detection are key diagnostic markers for the detection of invasive Aspergillosis.

Clinical Details

Clinical manifestations range from non-invasive allergic broncho-pulmonary aspergillosis, and aspergilloma, to invasive pulmonary aspergillosis, chronic necrotising pulmonary aspergillosis, and occasionally extra pulmonary manifestations involving organs like the liver, kidney, GI tract, eyes, brain and skin. Invasive and extrapulmonary manifestations are particularly seen in immunocompromised hosts such as those with underlying haematological malignancies, transplant recipients, or those receiving long-term immunosuppressive therapies. Pulmonary aspergillosis has been associated with some risk groups of individuals infected with SARS-CoV-2.

Building works in the healthcare setting poses the risk of nosocomial aspergillosis in vulnerable patient populations, especially where appropriate infection prevention and control measures have not been adequately implemented.

Aspergillus infections usually start in the lung following inhalation of environmental Aspergillus spores. Presenting symptoms of invasive pulmonary aspergillosis include fever, chest pain, and haemoptysis.

Galactomannan, a cell wall component of Aspergillus is a key diagnostic marker for the detection of invasive aspergillosis. Evidence of infection is usually supported by clinical history, radiological findings, diagnostic markers including galactomannan and serum β-d glucan, histology, and pathogen identification by culture or PCR.

As invasive aspergillosis is associated with significant morbidity and mortality early diagnosis and treatment is key.

Case Study
At Enfer Medical, we have integrated a cutting-edge and fully automated WASPLab® (Walk Away Specimen Processor) that has significantly enhanced our testing capabilities to ensure the highest of quality when processing patient samples.
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WASPLab® at Enfer Medical
Our entire microbiology workflow has been optimized using automation and highly sophisticated robots to ensure uninterrupted incubation for rapid bacterial growth and improved turnaround times for patients.
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Our Services

Service
Health & Wellness
General health and wellness testing can include a variety of tests, depending on the needs of the individual or recommendations of
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Service
Sexual Health
Regular STI screening facilitates early treatment and reduces the long-term consequences of infection.
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Service
Respiratory Health
Rapid early pathogen identification has important treatment and infection control implications. See our range of tests here.
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Reproductive & Female Health
Hormonal analysis is hugely beneficial to identifying problems that can arise during the reproductive years.
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Sample Type &
Volume Required

5ml venous serum or Bronchoalveolar lavage (BAL)

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Transporting
Samples

In addition to the packaging of samples, the transport/delivery of clinical samples to the laboratory is required to be in adherence to all national regulations for the safe transport of biological materials. Enfer Medical provides a fully compliant logistics service, aligned with clients’ testing requirements.

Prompt transport of specimens:
To ensure prompt testing of samples and release of results within the published test turnaround times, samples should arrive to the laboratory by 18:00. Test turnaround time is measured from receipt of the sample at the laboratory until the time the authorised results are reported to users.

Acceptance/Rejection
of Samples

In rare cases specimens may not be suitable for testing on arrival to the laboratory. In that case the sample will be rejected at the receipt stage and the service user will be notified immediately and an explanation as to why the sample could not be processed will be provided. Reasons why samples cannot be processed include but are not limited to:

  • Samples received beyond the stability limits and/or not at the correct temperature indicated for each test.
  • Incorrect sample type received.
  • Leaking samples, sample not received or sample insufficient for analysis as stated below within sample requirements.
  • Non-compliant samples or request forms i.e. those missing sample date information, missing sample test request and/or missing sample site/type information.
  • Samples received without the necessary patient identifiers.
Clients will be provided with guidance on Sample Receipt Anomalies.

Our Services

Service
Health & Wellness
General health and wellness testing can include a variety of tests, depending on the needs of the individual or recommendations of
Find Out More
Service
Sexual Health
Regular STI screening facilitates early treatment and reduces the long-term consequences of infection.
Find Out More
Service
Respiratory Health
Rapid early pathogen identification has important treatment and infection control implications. See our range of tests here.
Find Out More
Service
Reproductive & Female Health
Hormonal analysis is hugely beneficial to identifying problems that can arise during the reproductive years.
Find Out More
Service
All Services
View the full suite of services at Enfer Medical here.......
Find Out More
Result Values:
Qualitative results for Aspergillus Galactomannan will be reported as
Qualitative results
  • DETECTED
  • NOT DETECTED
  • INVALID
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