Possible causes of hyperphosphatemia include
- Advanced renal failure – GFR <30 significantly reduces the capacity to eliminate phosphate resulting in raised levels
- Inadequate renal excretion in the absence of chronic kidney disease also occurs in pseudohypoparathyroidism, hypoparathyroidism, and parathyroid suppression from hypercalcaemia due to vitamin A/D excess
- Phosphate overload from large transcellular shift of phosphate into the extracellular space that exceeds the kidneys ability to process it in a timely manner : tumour lysis syndrome, rhabdomyolysis, sepsis, DKA
- Excessive oral phosphate administration
Possible cause of hypophosphataemia
Clinically significant acute hypophosphatemia occurs in relatively few clinical settings such as:
- Severe respiratory alkalosis
- After DKA treatment
- During carbohydrate refeeding in severely malnourished patients / starvation states / alcoholism patients
- In patients receiving TPN
- Severe respiratory alkalosis
- Acute alcohol use disorder
- Severe burns
- Long term steroid use