A 125

A 125 is primarily used in the investigation and management of suspected ovarian cancer. It is not a screening test but is requested when symptoms such as persistent bloating, abdominal pain, early satiety, or urinary frequency raise clinical concern.

Elevated CA 125

Elevated CA 125 levels support further investigation (for example, ultrasound or referral to gynaecology), but do not confirm cancer, as levels may also be raised in benign conditions including endometriosis, fibroids, pelvic inflammatory disease, pregnancy, or menstruation. CA 125 may be normal in early ovarian cancer, and repeat testing may be required if symptoms persist. It is also used to monitor treatment response and detect recurrence in patients with known ovarian cancer.