The European Society of Cardiology and European Atherosclerosis Society comment that the inverse association between plasma HDL-C and the risk of atherosclerotic CVD is amongst the most consistent and reproducible associations in observational epidemiology. Furthermore these guidelines also state that there is currently no randomized trial or genetic evidence to suggest that raising plasma HDL-C will reduce the future risk of atherosclerotic events.
The Irish heart foundation recommends the following targets:
Target Cholesterol and Triglycerides:
| Total cholesterol: | <5 mmol/l |
| LDL cholesterol: | <3 mmol/l |
| HDL cholesterol: | >1 mmol/l |
| Triglycerides: | < 2 mmol/l |
For people with heart disease or diabetes :
| Total cholesterol: | < 4.5 mmol/l |
| LDL cholesterol: | < 1.8 mmol/l |
There are several algorithms available to assess CVD risk and when to initiate treatment.
https://statindecisionaid.mayoclinic.org/index.php/statin/index?PHPSESSID=7t5s8vcrtmlilekvejb4pd91g4
https://academic.oup.com/eurheartj/article/41/1/111/5556353
https://www.escardio.org/Journals/ESC-Journal-Family/European-Journal-of-Preventive-Cardiology
